Description

Suitable for in vivo delivery of DNA, siRNA, miRNA, oligonucleotides and mRNA

in vivo-jetPEI^®-Man is the reagent of choice to deliver any type of nucleic acid to mediate gene expression or gene silencing in various tissues, with enhanced targeting to macrophages and dendritic cells.

in vivo-jetPEI^®-Man is a versatile reagent as it is suitable for the delivery of plasmid DNA, siRNA, shRNA, miRNA, oligonucleotides and mRNA.

Easy two-step protocol

in vivo-jetPEI^®-Man is a very easy-to-use delivery reagent. The protocol consists in preparing the nucleic acid and reagent separately in 5% glucose solution, mixing them together and then, after a 15 min incubation time at room temperature, injecting the nucleic acid/ in vivo-jetPEI^®-Man complexes formed into animal (Fig. 1 ).

Suitable for any animal model

in vivo-jetPEI^®-Man is ideal for nucleic acid delivery in mice. However, the protocol is so easy and versatile that it can be adapted to other species.

Our delivery experts are available to adapt our protocol to your animal model and provide you with starting conditions for your application (Please contact the technical support team at [email protected]).

Safe: no inflammatory response triggered

in vivo-jetPEI^®-Man offers a reliable and safe alternative to viral vectors as it does not induce any significant inflammatory response.